SunActive® IsoQ: Cyclosomal Quercetin-3-O-Glycoside

What is SunActiveIsoQ?

SunActive® IsoQ is Quercetin-3-O-Glycoside (Q3OG) encapsulated into cyclic maltodextrin
SunActive® IsoQ is derived from Rutin from Styphnolobium japonicum
Q3OG is the direct precursor of Quercetin that is absorbed into the body
Q3OQ is enzymatically converted into quercitin and its metabolites during absorption.
Q3OG is the activated form of Rutin and quercetin
Q3OG is a naturally occurring glycosylated form of quercitin with improved bioavalibility.
Q3OG is quite instable in water and under acidic conditions
Q3OG can be sensitive under certain formulation conditions
SunActive® IsoQ is a stabilized form of Q3OG
SunActive® IsoQ is 600 times better water soluble than Rutin or Quercetin
Significantly improved solubility and bioavailibilty compared to standard quercitin based on internal and published data.
SunActive® IsoQ is 100 times better absorbed than hesperidin
Vergleich mit Hesperidin ist schwer einzuordnen!

Why does SunActiveIsoQ stands Out?

Next-generation quercetin with advanced bioavailability
Designed to overcome the limitations of conventional quercetin
Superior dispersibility for high-performance formulations
A smart ingredient solution for longevity and healthy ageing products
Powerful support for antioxidant protection and wellness positioning
Versatile, efficient, and easy to formulate
Perfect for brands looking to innovate and differentiate
Science-driven performance for today’s consumer health market

For which target groups is SunActiveIsoQ relevant?

SunActiveIsoQ is especially relevant for these target groups:

Immune health consumers
It is relevant for consumers interested in daily immune support.
Active lifestyle and sports nutrition users
Athletes, fitness-focused consumers, and active adults are a good target group because sports performance and sports nutrition are among the key application areas for SunActiveIsoQ.
Cardiovascular health consumers
Adults interested in heart health are also relevant, as SunActiveIsoQ is described as cardioprotective and is positioned for cardiovascular health concepts.
Consumers seeking antioxidant support
People who actively look for antioxidant ingredients are an important group, because SunActiveIsoQ is marketed around quercetin’s antioxidant benefits.

Consumers interested in allergy support
Seasonal wellness and allergy-support users may also be a relevant target group, since allergy relief is listed among the quercetin-related benefits associated with SunActiveIsoQ.
Joint and mobility support consumers
Adults focused on mobility and joint comfort can be relevant as well, because Taiyo includes chondroprotective positioning for the ingredient.
Brands and formulators in supplements and functional foods
SunActiveIsoQ is highly important for B2B target groups too, especially supplement brands and product developers, because its water solubility and higher bioavailability help solve common quercetin formulation challenges.
Manufacturers looking for format flexibility
It is particularly relevant for companies developing modern delivery formats such as gummies, soft chews, drink mixes, and functional beverages, because the ingredient is promoted as easy to formulate across both powder and liquid applications.
Healthy ageing and longevity consumers
People looking to support vitality, resilience, and long-term wellness are a strong fit, because SunActiveIsoQ is positioned for healthy aging and offers much higher quercetin bioavailability than standard quercetin.

Recherche hat ergeben: Nur BV-Studien (in vitro und in vivo) mit SunActive IsoQ. Zum Einsatz nur indirekt über Quercitin.

What kind of applications are possible?

SunActiveIsoQ can be used in a wide range of , especially where conventional quercetin would be difficult to formulate because of poor solubility. SunActiveIsoQ is suitable for both powder and liquid applications.

Possible applications for SunActiveIsoQ:

Functional beverages
Ready-to-mix drink powders
Sachets / stick packs
Capsules
Tablets
Gummies
Soft chews
Confectionery-type supplements
Functional foods
Multi-ingredient dietary supplements
Water-based liquid formulations
Powder blends for daily wellness products

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How does SunActiveIsoQ fit into formulations?

SunActiveIsoQ can be used in formulations as a more formulation-friendly replacement for standard quercetin. Because it is quickly and completely soluble in water and designed for both powder and liquid applications, it helps developers build products that are easier to process.

From a product-development perspective, SunActiveIsoQ is especially useful in formulations when you want to:

Replace conventional quercetin with a form that is easier to formulate. SunActiveIsoQ is a perfect replacement for quercetin in multicomponent formulas, or as a source of quercetin in new formulas.
Build clear or water-based concepts where regular quercetin would be difficult to disperse or dissolve.
Create multi-benefit formulas for areas such as immune, cardiovascular, cellular, antioxidant, or active-lifestyle positioning. These are among the benefit areas highlighted in supplier and partner materials.
Because of the higher bioavailability of SunActiveIsoQ than free quercetin you may require lower levels
SunActiveIsoQ is patent protected
SunActiveIsoQ is not NOVEL in FOOD SUPPLEMENTS

Science Section – SunActive® IsoQ

What is SunActive® IsoQ?

SunActive® IsoQ is a next-generation quercetin ingredient based on Isoquercitrin (quercetin-3-O-glucoside, Q3G), a naturally occurring flavonoid glycoside derived from Styphnolobium japonicum.

Isoquercitrin represents a biologically relevant form of quercetin that is more readily absorbed compared to the aglycone form. In the body, it is enzymatically converted into quercetin and its metabolites during intestinal absorption.

SunActive® IsoQ uses a proprietary delivery system in which isoquercitrin is encapsulated in Cyclodextrins, improving its dispersibility and stability in aqueous environments.

The Bioavailability Challenge of Quercetin

Quercetin is widely recognized in scientific literature for its role as a dietary flavonoid. However, its application in nutritional products is limited by:

very low water solubility
poor and variable absorption
rapid metabolism after ingestion

These factors can significantly restrict systemic exposure after oral intake.

A Bioavailability-Driven Solution

SunActive® IsoQ was specifically developed to address these limitations.

By combining isoquercitrin with a cyclodextrin-based delivery system, the ingredient achieves:

markedly improved water dispersibility
enhanced stability in formulation
significantly increased bioavailability compared to standard quercetin

Preclinical and human pharmacokinetic data indicate that this formulation can substantially increase plasma levels of quercetin metabolites following oral intake.

Scientific Rationale

The improved performance of SunActive® IsoQ is based on two well-established scientific principles:

Glycosylation Improves Absorption
Quercetin glycosides such as isoquercitrin are absorbed more efficiently than free quercetin. Enzymes in the small intestine facilitate their conversion and uptake, leading to higher systemic availability.
Cyclodextrin Encapsulation Enhances Delivery
Cyclodextrins are widely used in food and pharmaceutical applications to improve the solubility and stability of poorly water-soluble compounds. Encapsulation can support:
- better dispersion in aqueous systems
- protection against degradation
- improved transport across biological membranes

What This Means for Product Development

The enhanced bioavailability profile of SunActive® IsoQ allows formulators to work with quercetin in a more efficient and versatile way.

This enables:

development of clear or water-based formulations
improved consistency in finished products
potential reduction of required dosage levels compared to conventional quercetin

SunActive® IsoQ is therefore particularly suitable for modern delivery formats such as functional beverages, powders, gummies, and multi-ingredient formulations.

Scientific Positioning

SunActive® IsoQ is best understood as an advanced delivery form of quercetin, designed to improve its bioavailability and formulation performance.

While quercetin itself has been widely studied in the context of antioxidant and physiological processes, SunActive® IsoQ focuses on optimizing the delivery and absorption of this well-known flavonoid.

Note on Health Claims

In line with current European regulations, no specific health claims for quercetin or isoquercitrin have been authorized by the European Food Safety Authority.

SunActive® IsoQ is therefore positioned based on its technological and pharmacokinetic advantages rather than specific physiological claims.

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